![]() ![]() leukocytes in inflammation and platelets in blood clotting, the reverse takes place where the temporal loss of adhesion occurs during the migration of skin cells in wound healing to replace lost cells, on the other hand, defective cellular adhesion in malignancy promotes spread of cancer cells and occurrence of metastasis. Immunoglobulin superfamily: the molecules of this family are Ca +2– independent CAMs and they are involved in cell-to-cell adhesion, they are a large family that includes vascular cell adhesion Molecule (V-CAM) and neural cell adhesion molecule (N-CAM) which plays an important role in nervous system development.Ĭell adhesion is a dynamic process that is particularly evident where non-adhesive cells rapidly become adhesive e.g.Selectins are Ca +2-dependent CAMs and they are involved in cell-to-cell adhesion. Cadherins are Ca +2-dependent CAMs and they are involved in cell-to-cell adhesion.Integrins are Ca +2-dependent CAMs and they are involved mainly in cell-to-extracellular matrix adhesion.affected by the extracellular calcium ions concentration, whereas others are Ca +2 independent. The main CAMs include integrins, cadherins, selectins, and immunoglobulin superfamily, CAMs may be Ca +2-dependant i.e. The cytoplasmic domain is attached to the cytoskeleton of the cell through linker Proteins.Intramembranous (transmembrane) domain.Extracellular (EC) domain binds with the other CAMs of adjacent cells or extracellular matrix proteins.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |